Cardiovascular Physiology
(The course with a heart!)
Outline Of Lectures, Labs & Readings
Lecture - in Harder 103
Tues.- Thurs.11:10-12:30
Lab - in 316 or Harder 103 if Lecture 1rst
updated 8/26/2010
Outline now current through Dec.10
Warning Forever Under Construction!!!!!!
| Month | Orig. Date | Lecture topic/Added Readings | Smith & K. 3 | Berne & L. 8*/other |
|---|---|---|---|---|
|
I. General Principles
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| Sept. | 04 | Organizational / Decisons as to approach / Intro to hemodynamics? | Ch. 1 | Ch.1 |
| 09 | Hemodynamics I | 16-30 | 115-133 | |
| 10 | Hemodynamics II Applications HO, Vogel problem | 16-30 | 115-133 | |
| 11 |
(Lec) Cardiac Mechanics/Structure-Functional anatomy advice-concentrate on cardiac cycle B&L fig 3-11, S&K fig. 3.5 (lab) Progressive Anemia - web-HUMAN - effects on CO, O2A, O2V & VENT |
1-5,31-46 | 1-5, 66-78 | |
| 16 | Cardiac Mechanics/ Cardiac Cycle- functional mechanics - Applications HO | 31-46 | 66 [contractility]-78 [Fick] | |
| 17 |
Mechanics Clinical Case I - Mitral Stenosis data + questions (lab) Cardiac gross & microanatomy - Da 316 Central Vascular Anatomy - Calf Heart valve ring & base to apex dissections, Anatomy atlas - plates 200-01,03-04,06,08-013,2016 (ie.all in 200 series) |
Case HO + questions | ||
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II. The Heart
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| 18 | (Lec) Cardiac Cellular Physiology- Mechanical Activity I - Preload, Afterload, Contractility - 1) Ca2+ mobilizing mechanisms 2) contractility - cell & whole heart | 71-88 | 55-67 | |
| 23 | Cardiac Cellular Physiology- Cell Electrical Activity I | 47-58 | 7-31 | |
| 24 |
Cardiac Cellular Physiology- Cell Electrical Activity II - Applications HO - see email for revisions to #6 & #10. Revised handout (lab) Autonomic Control of Cardiovascular Reflexes - part 1 - ECG recording of human reflexes & preliminary HRV analysis |
47-58 | 7-34, 39-40 + fig. 2-34 | |
| 25 | (Lec)Electrocardiography I- Basics, scalar cardiography, Rate & Rhythm Disturbances | 59-70* | 43-51 [omit the vector material: 43, Standard Limb Leads->46, Box 2-11] | |
| 30 | Electrocardiography II- Applications, vector cardiography | 59-70 | 43-51 | |
| Oct. | 01 |
(lec) Cardiographic problems/analysis - discussion - ECG HO (lab) Autonomic Control of Cardiovascular Reflexes - part 2- ECG recording of human reflexes continued & HRV analysis of autonomic tone - separation of cold immersion and face immersion components |
59-70 |
43-51 *, ECG HO Anemia HO |
| 02 | Cardiac Output- Concepts, Classical Synthesis, Starling (Starling HO) | 116-121, 77-82 |
98-113 83-95 (skim) |
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| 07 | Cardiac Output- Control I, Guyton Analysis (Basic CO-VReturn curves HO) | 110-116 | 199-213 | |
| 08 |
Cardiac Output- Control II ( CO-VR concluded - Applications - Heart failure/sympathetic stimulation/decompensated failure (lab) Presentation of Autonomic Reflexes as evaluated via HRV analysis |
121-127 | 199-213, 76-80, 83-95 | |
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III. The peripheral vascular system
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| 09 |
(lec) Case Conference II- Congenital defects (note: This topic continues below with the CV development section) |
45-46, 259-61 S&K fig 1.8, 3.7,3.8 |
case handout | |
| 14 | Microcirculation 1- Exchange, Capillaries, Lymphatics | 128-137 | Chap. 7 | |
| 15 |
(lec) Microcirculation2 - Edema (lab) Vectorcardiography - basic recording, construction of six lead frontal plane cardiogram, study of effect of respiration on cardiac frontal vector direction & size |
137-139 | Chap. 7 | |
| 16 | => Examination #1 - it's over!!! Pick up readings for nexts week's topic Friday | |||
| 21 |
CV development I/Congenital cardiovascular defects - Fetal Circulation |
handout - Embryology HO, sample data from defects | B&L 264-268 plus below | |
| 22 |
CV development II/Embryology of the CV system, analysis of congenital defects and central vascular shunts - atrial, ventricular and ductus shunts, transposition of the great vessels, tetrology of Fallot/ - analysis of 4 mini-congenital defects cases (lab) - web-HUMAN - locate the congenital cardiovascular shunt |
handout - Embryology HO, sample data from defects |
1- Embryology of the heart 2- Fetal & Perinatal Circulation 3- Genetic Blueprint... - skim 4- Neuropeptide Y - Current Research - FYI & see B&L fig. 4-5 |
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| 23 |
(lec) Guest class - Kathleen Getty - "arrhythmia ablations, pacemakers and defibrillators" Thanks! Great class. |
Review your cardiac electrophys! | ||
| 28 |
Arterial pressure(AP)1- determinants/measurement 11 questions for discussion on AP measurement (HO) |
S&K ch6 |
B&L Box 6-2, fig. 6-16 B&L Ch6 (optional) |
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| 29 |
Arterial pressure(AP)2 - Control/short term (lab) Pressure-Flow I - anesthesia, recording ECG, blood pressure instrumentation/calibration |
S&K 161-178 | B&L 187-193 | |
| 30 | Arterial pressure(AP)3 - Control/ long term | S&K 178-9 | B&L TBA, HO | |
| Nov. | 04 | Control of Q-P 1 - Principles of CV Pharmacology I- Autonomic NS neurochemicals and receptors Shepard HO- 1) Principles 2) Adrenergic agonsists & antagonists 3) systemic response to NE |
*read 1rst Pharm lecs mostly handout based |
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| 06 | (lab) Electromagnetic Flow Measurements in acute preparations I - introduction/ surgery for flow masurements | |||
| 05 |
Exam #2 - all or partly in web-HUMAN w/ in class analysis Likely topics: Control of arterial blood pressure in web-HUMAN and Functional Shunt Analysis Final Paper Guidelines handouts distriibuted |
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| 11 |
1) Control of Q-P 2- Principles of CVPharmacology II read: Shepard HO, use outline HO |
S & K Ch.9 esp. 199- |
B & L Ch.8 | |
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IV. Organ Circulation
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| 12 |
web-HUMAN - Creation of 3 modules 1) Systemic response to NE infusion 2) Systemic response to an E infusion 3) Use of adrenergic blockers - prep: scrutinize variables & parameters list |
S&K 191-198 | B&L Ch 10 | |
| 13 | (lab) Electromagnetic Flow Measurements in acute preparations II - full preparation & recording | |||
| see 19 | Case Conference III: Coronary artery disease -HO - Reading resources --> | S&K 191-198 | B&L Ch 10 | |
| 18 | Organ Circulation1- pulmonary + pulmonary discussion HO questions | 215-219 | 250-255 | |
| 19 |
Organ Circulation2- coronary 1(basic characteristics, myocardial energetics) + coronary circ. discussion questions (HO) - plus read S&K IHD esp. 284-288 Case Conference III: Coronary artery disease -HO - Reading resources, see listing above |
191-8 85-88 |
Ch.10 | |
| 20 | Organ Circulation3- renal (& blood pressure control) + HO questions |
198-204+ review Long term BP control |
255-259 | |
| 25 | Organ Circulation4 - cerebral, other + HO questions | 182-191 | 247-250 | |
| Thanksgiving Vacation 26-30 | ||||
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IV. Integrative & Pathologic Cardiovascular Physiology
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| Dec. | 02 | Heart Disease & Heart Failure | 274-299 | 93,213-16,Ch10, |
| 03 |
Case Conference IV- Heart Disease and Heart Failure - case HO Last date for final paper topic approval |
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| 04 | Hemorrhage & shock | 311-327, 267-270 | 278-285 | |
| 09 |
Hypertension - lecture Hypertension of unknown origin (pheochromocytoma) - web-HUMAN - lab |
303, 309-311, 146 | ||
| 10 |
Final Symposium in lab (Harder 103) Papers due 4:30 * Exam III -optional at your choice or mine |
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Schedule of Major Clinical Case Conferences
| Date | Case | Location |
| Sept. 17 | Mitral stenosis | in lab |
| Oct. 09 | Congenital cardiac defects | in lab |
| Nov. 19 | Coronary artery disease | in lab |
| Dec. 03 | Heart Failure | in lab |
General information
1) Readings - Texts & Articles
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S&K =Circulatory Physiology- the essentials (3rd ed.) Smith, J. and Kampine, J.
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B&L= Cardiovascular Physiology (8 th ed.) Berne, R. & Levy, M.
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Articles - listed on the outline as lnks or as handouts, usually under the Berne & Levy column
2) Handouts H or HO a) case study handout b) journal article handout c) other text source
3) Attendance is required (see course hardcopy handout)
4) Grades- Exam average 75%, lab average 25% (including final paper & presentation)
- there are sometimes announced half-exams
5) All are expected to read ahead; lecture does not 'repeat' the reading but compliments it.
* Articles are picked on a rolling basis from current literature. Citations will be posted as they are selected.