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Cardiovascular Physiology

(The course with a heart!)

Outline Of Lectures, Labs & Readings

Lecture - in Harder 103

Tues.- Thurs.11:10-12:30

Lab - in 316 or Harder 103 if Lecture 1rst

updated 8/26/2010

Outline now current through Dec.10

Warning Forever Under Construction!!!!!!

Month Orig. Date Lecture topic/Added Readings Smith & K. 3 Berne & L. 8*/other

I. General Principles

Sept. 04 Organizational / Decisons as to approach / Intro to hemodynamics? Ch. 1 Ch.1
  09 Hemodynamics I 16-30 115-133
  10 Hemodynamics II Applications HO, Vogel problem  16-30  115-133
  11

(Lec) Cardiac Mechanics/Structure-Functional anatomy advice-concentrate on cardiac cycle B&L fig 3-11, S&K fig. 3.5


(lab) Progressive Anemia - web-HUMAN - effects on CO, O2A, O2V & VENT

1-5,31-46 1-5, 66-78 
  16  Cardiac Mechanics/ Cardiac Cycle- functional mechanics - Applications HO  31-46  66 [contractility]-78 [Fick]
  17 

Mechanics Clinical Case I - Mitral Stenosis data + questions


(lab) Cardiac gross & microanatomy - Da 316

Central Vascular Anatomy - Calf Heart valve ring & base to apex dissections,

Anatomy atlas - plates 200-01,03-04,06,08-013,2016 (ie.all in 200 series)

  Case HO + questions 

 II. The Heart     

  18  (Lec) Cardiac Cellular Physiology- Mechanical Activity I - Preload, Afterload, Contractility - 1) Ca2+ mobilizing mechanisms 2) contractility - cell & whole heart  71-88  55-67 
  23  Cardiac Cellular Physiology- Cell Electrical Activity I  47-58  7-31 
  24 

Cardiac Cellular Physiology- Cell Electrical Activity II - Applications HO - see email for revisions to #6 & #10. Revised handout


(lab) Autonomic Control of Cardiovascular Reflexes - part 1 - ECG recording of human reflexes & preliminary HRV analysis 

47-58  7-34, 39-40 + fig. 2-34 
  25  (Lec)Electrocardiography I- Basics, scalar cardiography, Rate & Rhythm Disturbances  59-70*  43-51 [omit the vector material: 43, Standard Limb Leads->46, Box 2-11] 
  30  Electrocardiography II- Applications, vector cardiography  59-70  43-51 
 Oct. 01 

(lec) Cardiographic problems/analysis - discussion - ECG HO


(lab) Autonomic Control of Cardiovascular Reflexes - part 2- ECG recording of human reflexes continued & HRV analysis of autonomic tone

- separation of cold immersion and face immersion components 

59-70 

43-51 *, ECG HO

Anemia HO

  02  Cardiac Output- Concepts, Classical Synthesis, Starling (Starling HO)  116-121, 77-82 

98-113

83-95 (skim) 

  07  Cardiac Output- Control I, Guyton Analysis (Basic CO-VReturn curves HO)  110-116  199-213 
  08 

Cardiac Output- Control II ( CO-VR concluded - Applications - Heart failure/sympathetic stimulation/decompensated failure


(lab) Presentation of Autonomic Reflexes as evaluated via HRV analysis 

121-127  199-213, 76-80, 83-95 

III. The peripheral vascular system     

  09 

(lec) Case Conference II- Congenital defects

(note: This topic continues below with the CV development section) 

45-46, 259-61


S&K fig 1.8, 3.7,3.8 

case handout 
  14  Microcirculation 1- Exchange, Capillaries, Lymphatics  128-137  Chap. 7 
  15

(lec) Microcirculation2 - Edema


(lab) Vectorcardiography - basic recording, construction of six lead frontal plane cardiogram, study of effect of respiration on cardiac frontal vector direction & size 

137-139  Chap. 7 
  16  => Examination #1 - it's over!!! Pick up readings for nexts week's topic Friday     
  21 

CV development I/Congenital cardiovascular defects - Fetal Circulation

handout - Embryology HO, sample data from defects B&L 264-268 plus below
  22 

CV development II/Embryology of the CV system, analysis of congenital defects and central vascular shunts - atrial, ventricular and ductus shunts, transposition of the great vessels, tetrology of Fallot/ 

- analysis of 4 mini-congenital defects cases


(lab) - web-HUMAN - locate the congenital cardiovascular shunt

handout - Embryology HO, sample data from defects 

1- Embryology of the heart

2- Fetal & Perinatal Circulation

3- Genetic Blueprint... - skim

4- Neuropeptide Y - Current Research - FYI & see B&L fig. 4-5 

  23 

(lec) Guest class - Kathleen Getty - "arrhythmia ablations, pacemakers and defibrillators"

Thanks! Great class. 

   Review your cardiac electrophys!
  28 

Arterial pressure(AP)1- determinants/measurement 

11 questions for discussion on AP measurement (HO) 

S&K ch6 

B&L Box 6-2, fig. 6-16

B&L Ch6 (optional) 

  29 

Arterial pressure(AP)2 - Control/short term


(lab) Pressure-Flow I - anesthesia, recording ECG, blood pressure instrumentation/calibration 

S&K 161-178 B&L 187-193 
  30  Arterial pressure(AP)3 - Control/ long term  S&K 178-9  B&L TBA, HO 
Nov. 04 Control of Q-P 1 - Principles of CV Pharmacology I- Autonomic NS neurochemicals and receptors Shepard HO- 1) Principles 2) Adrenergic agonsists & antagonists 3) systemic response to NE

*read 1rst

Pharm lecs mostly handout based

 
  06 (lab) Electromagnetic Flow Measurements in acute preparations I - introduction/ surgery for flow masurements    
  05

Exam #2 - all or partly in web-HUMAN w/ in class analysis

Likely topics: Control of arterial blood pressure in web-HUMAN and Functional Shunt Analysis

Final Paper Guidelines handouts distriibuted

   
  11

1) Control of Q-P 2- Principles of CVPharmacology II

read: Shepard HO, use outline HO

S & K Ch.9

esp. 199-

B & L Ch.8

IV. Organ Circulation

  12

web-HUMAN - Creation of 3 modules

1) Systemic response to NE infusion 2) Systemic response to an E infusion 3) Use of adrenergic blockers - prep: scrutinize variables & parameters list

S&K 191-198 B&L Ch 10
  13 (lab) Electromagnetic Flow Measurements in acute preparations II - full preparation & recording    
  see 19 Case Conference III: Coronary artery disease -HO - Reading resources --> S&K 191-198 B&L Ch 10
  18  Organ Circulation1- pulmonary + pulmonary discussion HO questions  215-219  250-255 
  19 

Organ Circulation2- coronary 1(basic characteristics, myocardial energetics) + coronary circ. discussion questions (HO) - plus read S&K IHD esp. 284-288


Case Conference III: Coronary artery disease -HO - Reading resources, see listing above 

191-8

85-88

 
Ch.10 
  20  Organ Circulation3- renal (& blood pressure control) + HO questions 

198-204+ review

Long term BP

control  

255-259 
  25  Organ Circulation4 - cerebral, other + HO questions  182-191  247-250 
Thanksgiving Vacation 26-30     

IV. Integrative & Pathologic Cardiovascular Physiology

Dec. 02 Heart Disease & Heart Failure 274-299 93,213-16,Ch10,
  03

Case Conference IV- Heart Disease and Heart Failure - case HO

Last date for final paper topic approval

   
  04 Hemorrhage & shock 311-327, 267-270 278-285
  09

Hypertension - lecture


Hypertension of unknown origin (pheochromocytoma) - web-HUMAN - lab 

 303, 309-311, 146  
  10 

Final Symposium in lab (Harder 103) Papers due 4:30

* Exam III -optional at your choice or mine

   

Schedule of Major Clinical Case Conferences

Date Case Location
Sept. 17 Mitral stenosis in lab
Oct. 09 Congenital cardiac defects in lab
Nov. 19 Coronary artery disease in lab
Dec. 03 Heart Failure in lab

General information

1) Readings - Texts & Articles

2) Handouts H or HO a) case study handout b) journal article handout c) other text source

3) Attendance is required (see course hardcopy handout)

4) Grades- Exam average 75%, lab average 25% (including final paper & presentation)
- there are sometimes announced half-exams

5) All are expected to read ahead; lecture does not 'repeat' the reading but compliments it.

* Articles are picked on a rolling basis from current literature. Citations will be posted as they are selected.

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