Month	Orig.Date	Lecture topic/Added Readings	Smith & K. 3	Berne & L. 8* /other
I. General Principles
Sept.	04	Organizational / Decisons as to approach / Intro to hemodynamics?	Ch. 1	Ch.1
	09	Hemodynamics I	16-30	115-133
	10	Hemodynamics II Applications HO, Vogel problem	16-30	115-133
	11	(Lec) Cardiac Mechanics/Structure-Functional anatomy advice-concentrate on cardiac cycle B&L fig 3-11, S&K fig. 3.5 ______________________________________________________________ (lab) Progressive Anemia - web-HUMAN - effects on CO, O2A, O2V & VENT	1-5,31-46	1-5, 66-78
	16	Cardiac Mechanics/ Cardiac Cycle- functional mechanics - Applications HO	31-46	66 [contractility]-78 [Fick]
	17	Mechanics Clinical Case I - Mitral Stenosis data + questions ______________________________________________________________ (lab) Cardiac gross & microanatomy - Da 316 Central Vascular Anatomy - Calf Heart valve ring & base to apex dissections, Anatomy atlas - plates 200-01,03-04,06,08-013,2016 (ie.all in 200 series)		Case HO + questions
II. The Heart
	18	(Lec) Cardiac Cellular Physiology- Mechanical Activity I - Preload, Afterload, Contractility - 1) Ca2+ mobilizing mechanisms 2) contractility - cell & whole heart	71-88	55-67
	23	Cardiac Cellular Physiology- Cell Electrical Activity I	47-58	7-31
	24	Cardiac Cellular Physiology- Cell Electrical Activity II - Applications HO - see email for revisions to #6 & #10. Revised handout ________________________________________________________________________ (lab) Autonomic Control of Cardiovascular Reflexes - part 1 - ECG recording of human reflexes & preliminary HRV analysis	47-58	7-34, 39-40 + fig. 2-34
	25	(Lec)Electrocardiography I- Basics, scalar cardiography, Rate & Rhythm Disturbances	59-70*	43-51 [omit the vector material: 43, Standard Limb Leads->46, Box 2-11 ]
	30	Electrocardiography II- Applications, vector cardiography	59-70	43-51
Oct.	01	(lec) Cardiographic problems/analysis - discussion - ECG HO ______________________________________________________________ (lab) Autonomic Control of Cardiovascular Reflexes - part 2- ECG recording of human reflexes continued & HRV analysis of autonomic tone - separation of cold immersion and face immersion components	59-70	43-51 *, ECG HO Anemia HO
	02	Cardiac Output- Concepts, Classical Synthesis, Starling (Starling HO)	116-121, 77-82	98-113 83-95 (skim)
	07	Cardiac Output- Control I, Guyton Analysis (Basic CO-VReturn curves HO)	110-116	199-213
	08	Cardiac Output- Control II ( CO-VR concluded - Applications - Heart failure/sympathetic stimulation/decompensated failure ______________________________________________________________ (lab) Presentation of Autonomic Reflexes as evaluated via HRV analysis	121-127	199-213, 76-80, 83-95
III. The peripheral vascular system
	09	(lec) Case Conference II- Congenital defects (note: This topic continues below with the CV development section)	45-46, 259-61 --- S&K fig 1.8, 3.7,3.8	case handout
	14	Microcirculation 1- Exchange, Capillaries, Lymphatics	128-137	Chap. 7
	15	(lec) Microcirculation2 - Edema ______________________________________________________________ (lab) Vectorcardiography - basic recording, construction of six lead frontal plane cardiogram, study of effect of respiration on cardiac frontal vector direction & size	137-139	Chap. 7
	16	=> Examination #1 - it's over!!! Pick up readings for nexts week's topic Friday	-----	-----
	21	CV development I / Congenital cardiovascular defects - Fetal Circulation	handout - Embryology HO, sample data from defects	B&L 264-268 plus below
	22	CV development II / Embryology of the CV system, analysis of congenital defects and central vascular shunts - atrial, ventricular and ductus shunts, transposition of the great vessels, tetrology of Fallot / - analysis of 4 mini-congenital defects cases ________________________________________________________________ (lab) - web-HUMAN - locate the congenital cardiovascular shunt	handout - Embryology HO, sample data from defects	1- Embryology of the heart 2- Fetal & Perinatal Circulation 3- Genetic Blueprint... - skim 4- Neuropeptide Y - Current Research - FYI & see B&L fig. 4-5
	23	(lec) Guest class - Kathleen Getty - "arrhythmia ablations, pacemakers and defibrillators" Thanks! Great class.	.	Review your cardiac electrophys!
	28	Arterial pressure(AP)1- determinants/measurement 11 questions for discussion on AP measurement (HO)	S&K ch6	B&L Box 6-2, fig. 6-16 B&L Ch6 (optional)
	29	Arterial pressure(AP)2 - Control/short term _______________________________________________________________________ (lab) Pressure-Flow I - anesthesia, recording ECG, blood pressure instrumentation/calibration	S&K 161-178	B&L 187-193
	30	Arterial pressure(AP)3 - Control/ long term	S&K 178-9	B&L TBA, HO
Nov.	04	Control of Q-P 1 - Principles of CV Pharmacology I- Autonomic NS neurochemicals and receptors Shepard HO- 1) Principles 2) Adrenergic agonsists & antagonists 3) systemic response to NE	*read 1rst Pharm lecs mostly handout based	----
	06	(lab) Electromagnetic Flow Measurements in acute preparations I - introduction/ surgery for flow masurements	----	----
	05	Exam #2 - all or partly in web-HUMAN w/ in class analysis Likely topics: Control of arterial blood pressure in web-HUMAN and Functional Shunt Analysis Final Paper Guidelines handouts distriibuted	-----	-----
	11	1) Control of Q-P 2- Principles of CVPharmacology II read: Shepard HO, use outline HO	S & K Ch.9 esp. 199-	B & L Ch.8
IV. Organ Circulation
	12	web-HUMAN - Creation of 3 modules 1) Systemic response to NE infusion 2) Systemic response to an E infusion 3) Use of adrenergic blockers - prep: scrutinize variables & parameters list	S&K 191-198	B&L Ch 10
	13	(lab) Electromagnetic Flow Measurements in acute preparations II - full preparation & recording	---	---
	see 19	Case Conference III: Coronary artery disease -HO - Reading resources -->	S&K 191-198	B&L Ch 10
	18	Organ Circulation1- pulmonary + pulmonary discussion HO questions	215-219	250-255
	19	Organ Circulation2- coronary 1(basic characteristics, myocardial energetics) + coronary circ. discussion questions (HO) - plus read S&K IHD esp. 284-288 ______________________________________________________________ Case Conference III: Coronary artery disease -HO - Reading resources, see listing above	191-8 85-88	Ch.10
	20	Organ Circulation3- renal (& blood pressure control) + HO questions	198-204+ review Long term BP control	255-259
	25	Organ Circulation4 - cerebral, other + HO questions	182-191	247-250
Thankgiving Vacation 26-30
IV. Integrative & Pathologic Cardiovascular Physiology
Dec.	02	Heart Disease & Heart Failure	274-299	93,213-16,Ch10,
	03	Case Conference IV- Heart Disease and Heart Failure - case HO Last date for final paper topic approval	-----	-----
	04	Hemorrhage & shock	311-327, 267-270	278-285
	09	Hypertension - lecture -------------------------------------------------------- Hypertension of unknown origin (pheochromocytoma) - web-HUMAN - lab	303, 309-311, 146
	10	Final Symposium in lab (Harder 103) Papers due 4:30 * Exam III -optional at your choice or mine	-----	-----

General information

1) Readings - Texts & Articles

• S&K =Circulatory Physiology- the essentials (3rd ed.) Smith, J. and Kampine, J.
• B&L= Cardiovascular Physiology (8 th ed.) Berne, R. & Levy, M.
• Articles - listed on the outline as lnks or as handouts, usually under the Berne & Levy column

2) Handouts H or HO a) case study handout b) journal article handout c) other text source

3) Attendance is required (see course hardcopy handout)

4) Grades- Exam average 75%, lab average 25% (including final paper & presentation)
- there are sometimes announced half-exams

5) All are expected to read ahead; lecture does not 'repeat' the reading but compliments it.

* Articles are picked on a rolling basis from current literature. Citations will be posted as they are selected.

More to come.......