Sylvia Franke McDevitt
@ Skidmore since 2006
Telephone: (518) 580-5076
Fax: (518) 580-5071
My research concentrates on different aspects of microbial metal homoeostasis: i) Mechanism of copper and silver resistance in Escherichia coli and ii) Influence of zinc on pathogenicity of Salmonella typhimurium .i) Mechanism of copper and silver resistance in E. coli
Why is this important?
a) transport from the periplasm into the surrounding medium is accomplished by a transport complex homologue to transporters involved in antibiotic resistance
ii) Influence of zinc on pathogenicity of Salmonella typhimurium
b) Silver ions are used as biocide in a time in which more and more antibiotic resistant pathogenic bacteria are emerging. Understanding silver resistance and how it spreads is essential to be able to “keep up” with the amazing ability of bacteria to adapt to their environment.
Rensing, C., and S. Franke. 11 January 2007, posting date. Chapter 184.108.40.206, Copper Homeostasis in Escherichia coli and Other Enterobacteriaceae . In A. Böck , R. Curtiss III, J. B. Kaper, F. C. Neidhardt, T. Nyström, K. E. Rudd, and C. L. Squires (ed.), EcoSal Escherichia coli and Salmonella: cellular and molecular biology . http://www.ecosal.org. ASM Press, Washington , D.C.
Franke, S. and C. Rensing. 2007. Acidophiles: mechanisms to tolerate metal and acid toxicity. In Physiology and Biochemistry of Extremophiles. Gerday, C., and N. Glansdorff , editors. ASM Press, Washington , D.C. 271-278. (publication date: April 2007)Franke, S. 2007. Microbiology of the Toxic Noble Metal Silver. In Molecular Microbiology of Heavy Metals (Microbiology Monographs, volume 6). Nies, D.H., and S. Silver, volume editors. Springer Berlin/Heidelberg. 343-355. (online posting date: 3 February 2007, print version publication date: May 2007)
Qin, J., B.P. Rosen, Y. Zhang, G. Wang, S. Franke and C. Rensing (2006) Properties and function of ArsM: a bacterial arsenite S-adenosylmethionine methyltransferase. PNAS 103:2075-2080.
Loftin * , I.R., S. Franke * , S.A. Roberts, A. Weichsel, A. Heroux, W.R. Montfort, C. Rensing and M.M. McEvoy (2005) A novel copper-binding fold for the periplasmic copper resistance protein CusF. Biochemistry 44:10533-10540. (* these authors contributed equally)
Hasman, H., S. Franke and C. Rensing (2005) Resistance to metals used in agricultural production. pp 99-114. In: (Aarestrup, F.M., and H.C. Wegener, eds.) Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington , D.C.
Haney, C.J., G. Grass, S. Franke and C. Rensing (2005) New developments in the understanding of the cation diffusion facilitator family. J Ind Microbiol Biotechnol 32:215-226.
Grass, G., S. Franke, N. Taudte, D.H. Nies, L.M. Kucharski, M.E. Maguire and C. Rensing (2005) The metal permease ZupT from Escherichia coli is a transporter with a broad substrate spectrum. J Bacteriol 187:1604-11.
Anton, A., A. Weltrowski, C.J. Haney, S. Franke, G. Grass, C. Rensing and D.H. Nies (2004) Characteristics of zinc transport by two bacterial cation diffusion facilitators from Ralstonia metallidurans CH34 and Escherichia coli . J Bacteriol 186:7499-507.
Grosse, C., A. Anton, T. Hoffmann, S. Franke, G. Schleuder and D.H. Nies (2004) Identification of a regulatory pathway that controls the heavy-metal resistance system Czc via promoter czcNp in Ralstonia metallidurans . Arch Microbiol. 182:109-18.
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