| 280-133 BCE |
| 280-275: Pyrrhic War in southern Italy and Sicily |
| 229-225: War with Illyria in western Greece: amici |
| 218-201: Second Punic War, resulting in Rome's defeat of Carthage in 202 at Zama (led by Publius Scipio Cornelius, now called "Africanus") |
| 221-205: Philip V of Macedon allies with Achaea and Aetolia in Greece in 221, and with Hannibal and Carthage in 215. 1st Macedonian War 215-205, ending in peace treaty with Rome in 205 |
| 201: Roman peace with Carthage, which becomes client state |
| 200:
Philip allies with Antiochus III (king 223-187)
of the Seleucid Empire vs. Ptolemy V Rhodes & Pergamum (king Attalus 241-197) appeal to Rome |
| 200-196: 2nd Macedonian War. Consul Publius Sulpicius Galba persuades Comitia Centuriata |
197: Battle of Cynoscephalae in Thessaly (Greece):
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| 197: Rome organizes Hispania Citerior ("Nearer Spain ") and Ulterior ("Farther Spain") into two provinces, adding to Corsica and Sardinia (227) and Sicily (211). Additional praetorships created to provide provincial governors |
| 195: Hannibal exiled from Carthage and joins Antiochus III (king 223-187) in Seleucia |
| 194: Rome grants Asia Minor to Antiochus III (who seized Thrace; lower Syria from Egypt) |
191: Rome + Rhodes + Pergamum (King Eumenes II, rules 197-158) vs. Antiochus III + Aetolia at Thermopylae (Philip V on the sidelines):
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| 179: Perseus, son of Philip, forges alliances with Greece's poor, foments rebellion by abolishing debts, interferes in Greek politics. |
| 172: Eumenes II (king 197-158) of Pergamum persuades Rome to wage war vs. Perseus |
| 172-167: Rome declares war = 3rd Macedonian War. |
| 168: L. Aemilius Paullus (consul) vs. Perseus + Greeks at Pydna in Thessaly
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| 150-147: Return of Achaean exiles & Roman oppression of Greeks leads to 4th Macedonian War; Andriscus, pretender to Macedonian throne, leads revolt; defeated in 147 and Rome turns Macedonia into a province |
| 151: M. Porcius Cato demands Carthago delenda est ("Carthage must be destroyed"); Carthage declares war on Masinissa (king 205-149) |
| 149: Rome begins siege of Carthage. Masinissa dies of old age. |
| 146: Lucius Mummius sacks Corinth to show Achaeans Rome's intent. P. Cornelius Scipio Aemilianus (son of L. Aemilius Paullus, adopted by Scipio) destroys Carthage. |
| 155-139: Viriathus leads revolt vs. Rome: Lusitanian War (western Spain), resulting in Roman conquest of Lusitania |
| 181-179, 153-151, 143-133: Celtiberian War (eastern Spain), resulting in destruction of Numantia by P. Cornelius Scipio Aemilianus |
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