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Biology Department
 
Jason Breves

Jason Breves

Assistant Professor of Biology

Address:
Dana Science Center, Room 345
Department of Biology
Skidmore College
Saratoga Springs, NY 12866

Telephone: (518) 580-5079
Fax: (518) 580-5071
E-mail: jbreves@skidmore.edu

Education:

Courses:

Research Interests:

My students and I employ a variety of fish models (zebrafish, Mozambique tilapia, mummichog and Atlantic salmon) to study how pituitary hormones, most notably prolactin and growth hormone, direct the concerted movements of ions and water across osmoregulatory tissues such as the gill, kidney and gut. While we have known that the endocrine system is essential to osmoregulation across vertebrate species, the molecular mechanisms of action remain poorly understood. The basic physiological processes that support osmoregulation are highly conserved across vertebrate species, making fish an excellent experimental model for understanding an array of human diseases associated with osmoregulatory dysfunction. Thus, a major focus of our research is to develop the zebrafish as a powerful genetic model to study how pituitary hormones participate in developmental kidney patterning and functional regulation. As organismal physiologists, our lab seeks to connect observations at the cellular and molecular levels with the physiology, development and natural histories of the organisms we study.

Lab Members (current and alumni):

Annaliese Chang '19, Damaris Chenoweth '17, James Doud '17, Chelsea Fujimoto '15, Alexandra Harney '21, Olivia Hayden '17, Bethany Hunt '17, Paige Keith '16, Victor Koltenyuk '20, Nastasia Nelson '20, Amanda Paskavitz '17, Silas Phipps-Costin '16, Christine Popovski '16, Ryan Springer-Miller '17, Eleanore Ritter '18, Rebecca White '19, Ketan Yerneni '17, Wenhui Zhao '18

Recent Publications:

Marshall WS, Breves JP, Doohan EM, Tipsmark CK, Kelly SP, Robertson GN, Schulte PM. 2017. claudin-10 isoform expression and cation selectivity change with salinity in salt-secreting epithelia of F. heteroclitus. Journal of Experimental Biology; In press.    

Yamaguchi Y, Breves JP, Haws MC, Lerner DT, Grau EG, Seale AP. 2017. Acute salinity tolerance and the control of two prolactins and their receptors in the Nile tilapia (Oreochromis niloticus) and Mozambique tilapia (O. mossambicus): a comparative study. General and Comparative Endocrinology; In press.

Breves JP, Keith PLK, Hunt BL, Pavlosky KK, Inokuchi M, Yamaguchi Y, Lerner DT, Seale AP, Grau EG. 2017. clc-2c is regulated by salinity, prolactin and extracellular osmolality in tilapia gill. Journal of Molecular Endocrinology 59(4): 391-402.

Breves JP, Fujimoto CK, Phipps-Costin SK, Einarsdottir IE, Björnsson BT, McCormick SD. 2017. Variation in branchial expression among insulin-like growth-factor binding proteins (igfbps) during Atlantic salmon smoltification and seawater exposure. BMC Physiology 17:2. Video Abstract.

Douros JD, Baltzegar DA, Mankiewicz JL, Taylor JD, Yamaguchi Y, Lerner DT, Seale AP, Grau EG, Breves JP, Borski RJ. 2017. Control of leptin by metabolic state and its regulatory interactions with pituitary growth hormone and hepatic growth hormone receptors and insulin like growth factors in the tilapia (Oreochromis mossambicus). General and Comparative Endocrinology 240: 227-237.

Breves JP, Inokuchi M, Yamaguchi Y, Seale AP, Hunt BL, Watanabe S, Lerner DT, Kaneko T, Grau EG. 2016. Hormonal regulation of aquaporin 3: opposing actions of prolactin and cortisol in tilapia gill. Journal of Endocrinology 230(3): 325-337.

Breves JP, Phipps-Costin SK, Fujimoto CK, Einarsdottir IE, Regish AM, Björnsson BT, McCormick SD. 2016. Hepatic insulin-like growth factor binding protein (igfbp) responses to food restriction in Atlantic salmon smolts. General and Comparative Endocrinology 233: 79-87.

Tipsmark CK, Breves JP, Rabeneck DB, Trubitt RT, Lerner DT, Grau EG. 2016. Regulation of gill claudin paralogs by salinity, cortisol and prolactin in Mozambique tilapia (Oreochromis mossambicus). Comparative Biochemistry and Physiology, Part A 199: 78-86.

Inokuchi M, Breves JP, Moriyama S, Watanabe S, Kaneko T, Lerner DT, Grau EG, Seale AP. 2015. Prolactin 177, prolactin 188 and extracellular osmolality independently regulate the gene expression of ion transport effectors in gill of Mozambique tilapia. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 309:R1251-R1263.

Furukawa F, Watanabe S, Seale AP, Breves JP, Lerner DT, Grau EG, Kaneko T. 2015. In vivo and in vitro effects of high-K+ stress on branchial expression of ROMKa in seawater-acclimated Mozambique tilapia. Comparative Biochemistry and Physiology, Part A 187: 111-118.

Douros JD, Baltzegar DA, Breves JP, Lerner DT, Seale AP, Grau EG, Borski RJ. 2014. Prolactin is a major inhibitor of Leptin A synthesis and secretion: studies utilizing a homologous Leptin A ELISA in the tilapia. General and Comparative Endocrinology 207: 86-93.

Breves JP, Tipsmark CK, Stough BA, Seale AP, Flack BR, Moorman BP, Lerner DT, Grau EG. 2014. Nutritional status and growth hormone regulate insulin-like growth factor binding protein (igfbp) transcripts in Mozambique tilapia. General and Comparative Endocrinology 207: 66-73.

Breves JP, Seale AP, Moorman BP, Lerner DT, Hopkins KD, Grau EG. 2014. Pituitary control of branchial NCC, NKCC and Na+, K+-ATPase alpha-subunit gene expression in Nile tilapia, Oreochromis niloticus. Journal of Comparative Physiology B 184: 513-523.

Seale AP, Stagg JJ, Yamaguchi Y, Breves JP, Soma S, Watanabe S, Kaneko T, Cnaani A, Harpaz S, Lerner DT, Grau EG. 2014. Effects of salinity and prolactin on gene transcript levels of ion transporters, ion pumps and prolactin receptors in Mozambique tilapia intestine. General and Comparative Endocrinology 206: 146-154.

Breves JP, McCormick SD, Karlstrom RO. 2014. Minireview: Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia. General and Comparative Endocrinology 203: 21-28.

Full List of Publications

Recent Abstracts/Presentations:

Breves JP, Keith PLK,Hunt BL, Pavlosky KK, Inokuchi M, Yamaguchi Y, Lerner DT, Seale AP, Grau EG. Multifactorial control of branchial clc-2c gene expression in tilapia: effects of salinity, prolactin and extracellular osmolality. 18th International Congress of Comparative Endocrinology, Jun 2017, Lake Louise, Canada

Marshall WS, Breves JP, Tipsmark CK, Kelly SP, Robertson GN, Schulte PM. Euryhaline mummichogs exposed to seawater and hypersaline conditions augment the cation-permeable paracellular pathway by differentially regulating claudin 10 isoforms. Society for Experimental Biology: Morphology Meets Physiology Symposium, Jun 2017, Gothenburg, Sweden.

Doud JM, Popovski CM, Ritter EJ, Tipsmark CK, Breves JP. Salinity-dependent expression of an ncc-like gene in the gill and opercular epithelium of euryhaline killifish. Experimental Biology, Apr 2017, Chicago, IL.

Springer-Miller RH, Chenoweth DA, Paskavitz AL, Regish AM, McCormick SD, Breves JP. Effect of cortisol on growth and gene expression of insulin-like growth-factor binding proteins (igfbps) in Atlantic salmon parr. Experimental Biology, Apr 2017, Chicago, IL.

Breves JP, Duffy TA, Einarsdottir IE, Bjornsson BT, McCormick SD. In vivo effects of 17alpha-ethinylestradiol, 17beta-estradiol and 4-nonylphenol on hepatic insulin-like growth-factor binding protein (igfbp) mRNA levels in Atlantic salmon. Society for Integrative and Comparative Biology, Jan 2017, New Orleans, LA.

Keith PLK, Hunt BL, Inokuchi MI, Yamaguchi Y, Seale AP, Lerner DT, Grau EG, Breves JP. Prolactin and extracellular osmolality regulate clc2c expression in tilapia. Experimental Biology, Apr 2016, San Diego, CA.

Phipps-Costin SK, Fujimoto CK, Einarsdottir IE, Regish AM, Bjornsson BT, McCormick SD, Breves JP. Insulin-like growth-factor binding protein (igfbp) responses to fasting in Atlantic salmon smolts. 15th Symposium of the Center for Neuroendocrine Studies, Univ. of Massachusetts, Sep 2015, Amherst, MA.

Breves JP, Inokuchi M, Yamaguchi Y, Seale AP, Watanabe S, Lerner DT, Kaneko T, Grau EG. Invited: Prolactin and cortisol direct branchial aquaporin 3 expression in euryhaline tilapia. 3rd Meeting of the North American Society for Comparative Endocrinology, Jun 2015, Ottawa, Canada.

Fujimoto CK, Phipps-Costin SK, McCormick SD, Breves JP. Variation in branchial expression among insulin-like growth-factor binding proteins (igfbps) during Atlantic salmon smoltification. Experimental Biology, Mar 2015, Boston, MA.

Phipps-Costin SK, Fujimoto CK, McCormick SD, Breves JP. Hepatic insulin-like growth-factor binding protein (igfbp) transcriptional responses to fasting in Atlantic salmon. Experimental Biology, Mar 2015, Boston, MA.

Breves JP, Inokuchi M, Yamaguchi Y, Seale AP, Watanabe S, Lerner DT, Kaneko T, Grau EG. Hormonal control of aquaporin 3 in tilapia gill: direct actions of prolactin and cortisol. Experimental Biology, Mar 2015, Boston, MA.

Selected Awards:

Scholander Award; American Physiological Society, Comparative and Evolutionary Physiology Section (2013)

Research Recognition Award; American Physiological Society, Comparative and Evolutionary Physiology Section (2013)

Ruth L. Kirschstein National Research Service Awards (T32/F32), National Institutes of Health, NIMH & NIDDK (2011-2013)

Memberships:

American Physiological Society (APS)

North American Society for Comparative Endocrinology (NASCE)

Society for Integrative and Comparative Biology (SICB)

Center for Neuroendocrine Studies (CNS), UMass Amherst

Sigma Xi

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