In Vitro Vascular Physiology and Metabolism Lab

1. investigating how blood vessels function in both health and disease, and
2. investigating how mitochondria (energy producing part of cells) function in health and disease. The two major methods by which we explore these questions are through:

  
Left: Professor Stephen Ives dissecting and mounting mouse aorta onto wire myograph chamber for study investigating the mechanisms of a high fat diet on blood vessel health. Right: Cheyanne Slocum, 2017, measures tissue weight for subseqent mitochondrial respiration measurements.

Isolated Vessel Wire Myography

Used to perform pharmacological experiments on isolated blood vessels under various physiological conditions (such as those seen during exercise) or comparing populations, such as aging.

Keldwin Taveras, 2017, and Josh Kalloo, 2017, generating pharmacological dose response curves in mouse aorta.

Permeabilized Tissue Assessment of Mitochondrial Function

Used to perform pharmacological experiments on isolated tissue under various physiological conditions (such as those seen during exercise).

Cheyanne Slocum, 2017, performing mitochondrial respiration measurements in mouse skeletal muscle.